By Olivier Civelli (auth.), Olivier Civelli, Qun-Yong Zhou (eds.)
Over the decade it's been proven that orphan G protein-coupled receptors (GPCRs) can be utilized as goals to find novel neuropeptides. A dozen neuropeptides were pointed out via this technique. each one of those neuropeptides has opened new doorways for our figuring out of basic physiological or behavioral responses. for instance the orexins, MCH and ghrelin hold basic roles in regulating meals consumption whereas neuropeptide S, neuromedin S, the prokineticins and the orexins are significant avid gamers in modulating sleep and circadian rhythms.
The chapters of this e-book overview the most recent learn within the box, so much of them are written by way of the unique discoverers of the respective novel neuropeptide. Emphasis is determined not just on their discovery but additionally on their practical value. due to the fact that a lot of those neuropeptides are a part of drug discovery courses, this e-book affects educational in addition to pharmaceutical research.
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Over the past decade it's been proven that orphan G protein-coupled receptors (GPCRs) can be utilized as objectives to find novel neuropeptides. A dozen neuropeptides were pointed out via this procedure. each one of those neuropeptides has opened new doorways for our knowing of basic physiological or behavioral responses.
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Additional resources for Orphan G Protein-Coupled Receptors and Novel Neuropeptides
Peptides 27:2193–2200 Wagner EJ, Ronnekleiv OK, Grandy DK, Kelly MJ (1998) The peptide orphanin FQ inhibits beta-endorphin neurons and neurosecretory cells in the hypothalamic arcuate nucleus by activating an inwardly-rectifying K+ conductance. Neuroendocrinology 67:73–82 Wang JB, Johnson PS, Imai Y, Persico AM, Ozenberger BA, Eppler CM, Uhl GR (1994) cDNA cloning of an orphan opiate receptor gene family member and its splice variant. FEBS Lett 348:75–79 Wick MJ, Minnerath SR, Roy S, Ramakrishnan S, Loh HH (1995) Expression of alternate forms of brain opioid orphan receptor mRNA in activated human peripheral blood lymphocytes and lymphocytic cell lines.
2005). In vitro, noradrenergic cells of the LC (Hagan et al. 1999), dopaminergic cells of the VTA (Nakamura et al. 2000), serotonergic cells of the DR (Brown et al. 2002; Liu et al. 2002), and histaminergic cells of the TMN (Yamanaka et al. 2002) are all activated by orexins (Fig. 2). Orexins also have a strong direct excitatory effect on cholinergic neurons of the BF (Eggermann et al. 2001), which also play an important role in regulating arousal (Alam et al. 1999). In addition, orexin neurons project to LDT/PPT cholinergic neurons.
J Neuroimmunol 81:184–192 Ploj K, Roman E, Bergstrom L, Nylander I (2001) Effects of neonatal handling on nociceptin/orphanin FQ and opioid peptide levels in female rats. Pharmacol Biochem Behav 69:173–179 Ploj K, Roman E, Nylander I (2002) Effects of maternal separation on brain nociceptin/orphanin FQ peptide levels in male Wistar rats. Pharmacol Biochem Behav 73:123–129 Polidori C, Calo G, Ciccocioppo R, Guerrini R, Regoli D, Massi M (2000) Pharmacological characterization of the nociceptin receptor mediating hyperphagia: identiﬁcation of a selective antagonist.
Orphan G Protein-Coupled Receptors and Novel Neuropeptides by Olivier Civelli (auth.), Olivier Civelli, Qun-Yong Zhou (eds.)