By Christopher D. Stubbs, Emanuel Rubin (auth.), Christer Alling, Ivan Diamond, Steven W. Leslie, Grace Y. Sun, W. Gibson Wood (eds.)
Alcohol abuse and alcoholism are overseas difficulties whose expenditures low-budget ly, psychologically and medically were good documented. Alcohol is a special drug in that the results of over the top use could have a deleterious impression on so much if now not all organs of the physique. The mind is likely one of the organs most influenced by way of over the top alcohol intake. results at the mind will be obvious in cognitive functionality, mind constitution and neurochemistry. over the last few years, there were major advances made in figuring out how alcohol impacts mind neurochemistry. This booklet examines 4 significant components, i. e. , membrane lipids, receptors and ion channels, moment messengers, and gene expression, the place major developments were made. The ebook is split into 4 sections in line with the 4 significant components. In every one part, information are tested that disguise a number methods from in vitro to in vivo stories. The part on membrane lipids contains fresh advancements in how ethanol impacts membrane ldl cholesterol domain names, polyunsaturated fatty acids, the reason and effects of phosphatidylethanol formation, and the modulation of membrane protein functionality through lipid-protein interplay. the second one part contains chapters on NMDA and 5-HT3 receptors, together with new points on alcohol neurotoxicity and the molecular heterogeneity which could underlie modifications in alcohol sensitivity in addition to chapters on GABA-gated chloride flux, and calcium channels.
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Additional info for Alcohol, Cell Membranes, and Signal Transduction in Brain
PhosphatidyOOositol from ethanol-fed rats confers membrane tolt7aDce to ethanol. Proc. Nail. Acad Sci. U. S. A. 83. 9398. Taraschi. S. Ellingson. A. Wu-Sun and E. Rubin. 1990. me tolerance after resumption of ethanol feeding. Biochim Biophys Acta 1021. 51. 30 Thomas. PD. and MJ. Pomansky. 1988. Cholesterol transfer between lipid vesicles. effect of phospholipids and gangliosides. Biocbem I 251. 55. Thumbofer. H. and H. Hauser. 1990. Uptake of cholesterol by small intestinal brusb border membrane is protein-mediated, Biochem.
S. -s. -s. ,l. -s. -s. ) Urouga, et al,. , 1991), while most studies have reported no effect. P. , 1984a). , 1985), while another study has reported decreases in synaptic plasma membrane concentrations following 21 days of intubation in rats fed a diet low in n-3 fatty acids, but not in rats fed diets with high n-3 concentrations (Z6rouga, et al,. 1991). Therefore, as discussed above regarding fatty acid levels in the blood, dietary PUPA status of the animal may be an important factor in determining the effects of ethanol on brain fatty acid composition.
S. r. r. r. -s. r. -s. r. -s. -s. r. -s. r. -s. -s. -s. -s. r. P. -s. -s. , 1991). Some researchers have studied ethanol effects on liver composition in primates fed ethanol in liquid diets for periods ranging from 10 months to several years and, again, the results have been inconsistent. , 1981). This same group did, however, find decreases in 20:4n6 in whole liver preparations in this species following a shorter period of consumption (10 months). Therefore, the inconsistencies in the results may have reflected different methodologies, or some other undefined variable.
Alcohol, Cell Membranes, and Signal Transduction in Brain by Christopher D. Stubbs, Emanuel Rubin (auth.), Christer Alling, Ivan Diamond, Steven W. Leslie, Grace Y. Sun, W. Gibson Wood (eds.)