By Roumen Pankov, Albena Momchilova (auth.), Venkatram Prasad Shastri, George Altankov, Andreas Lendlein (eds.)
This e-book summarizes the NATO complicated examine Workshop (ARW) on “Nanoengineered platforms for Regenerative drugs” that was once prepared lower than the auspices of the NATO defense via technology application. i need to thank NATO for assisting this workshop through a furnish to the co-directors. the target of ARW used to be to discover many of the elements of regenerative me- cine and to spotlight function of the “the nano-length scale” and “nano-scale platforms” in defining and controlling phone and tissue environments. the improvement of novel tissue regenerative recommendations require the mixing of recent insights rising from stories of cell-matrix interactions, mobile signalling techniques, developmental and structures biology, into biomaterials layout, through a structures procedure. The chapters within the ebook, written by way of the major specialists of their respective disciplines, disguise a large spectrum of issues starting from stem cellphone biology, developmental biology, ce- matrix interactions, and matrix biology to floor technology, fabrics processing and drug supply. we are hoping the contents of the booklet will galvanize the readership into constructing regenerative drugs paradigms that mix those aspects into cli- cally translatable suggestions. This NATO assembly don't have been winning with no the well timed support of Dr. Ulrike Shastri, Sanjeet Rangarajan and Ms. Sabine Benner, who assisted within the association and implementation of varied components of this assembly. thank you also are due Dr. Fausto Pedrazzini and Ms. Alison Trapp at NATO HQ (Brussels, Belgium). The dedication and endurance of Ms.
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Extra resources for Advances in Regenerative Medicine: Role of Nanotechnology, and Engineering Principles: Role of Nanotechnology, and Engineering Principles
Science 259:1014–1017 Hynes RO (1990) Fibronectins. Springer, New York Hynes RO (2002) Integrins: bidirectional, allosteric signaling machines. Cell 110:673–678 Jayaraman M, Meyer U, Buhner M, Joos U, Wiesmann HP (2004) Influence of titanium surfaces on attachment of osteoblast-like cells in vitro. Biomaterials 25:625–631 Kue R, Sohrabi A, Nagle D, Frondoza C, Hungerford D (1999) Enhanced proliferation and osteocalcin production by human osteoblast like MG-63 cells on silicon nitride ceramic discs.
This result is in agreement with the work of Deligianni et al. who reported an increased cellular interaction with increased surface roughness of sintered HA (Ginebra et al. 2004). Similarly to these and also other studies we observed a generally lower cell adhesion and proliferation on these apatite substrates than in the control TC polystyrene (Ginebra et al. 2004; Deligianni et al. 2001). The same trend was found also for cell proliferation. MG 63 cells grew much better on the surface of Coarse cement and significant differences between the two CPC substrates appeared from day 7, suggesting that osteoblasts on fine cements tended to stop earlier their proliferation.
Even on moderately wettable substrata (with water contact angle, WCA, around 60°) the FN reorganization is blocked (Altankov and Groth 1994). Moreover, this cellular activity is not specific only to FN, but similar altered cellular reorganization was recently reported for adsorbed FNG in contact with endothelial cells (Tzoneva et al. 2002). 2 Development of Late Fibronectin Matrix When fibroblasts are cultured in vitro they synthesize and tend to arrange secreted FN in a specific fibrillar pattern on the materials interface and such FN matrix is formed only in the presence of cells (Lutolf and Hubbell 2005).
Advances in Regenerative Medicine: Role of Nanotechnology, and Engineering Principles: Role of Nanotechnology, and Engineering Principles by Roumen Pankov, Albena Momchilova (auth.), Venkatram Prasad Shastri, George Altankov, Andreas Lendlein (eds.)