By M. Kohsaka, T. Shohmori and Y. Tsukada (Eds.)
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Extra resources for Advances in Dopamine Research. Proceedings of a Satellite Symposium to the 8th International Congress of Pharmacology, Okayama, Japan, July 1981
72, 287-296. , and Schwartz, J. (1979). Renal dopaminergic mechanisms. L. Imbs and J. ), Advances in the Biosciences, Vol. 20 Peripheral dopamine receptors, Pergamon Press, pp. 331-342. W. B. (1979). Multiple receptors for dopamine. Nature 277, 93-96. G. (1978). Pharmacology of 6,7-dihydroxy-2-dimethylaminotetralin (TL-99). I. Cardiovascular activity in the dog and cat. J. Pharmacol. Exp. Ther. 206, 239-247. I. (1982). Differential antagonism of postsynaptic (DA-,) and presynaptic (DA 2 ) peripheral dopamine receptors by substituted benzamides.
48 L. I. Goldberg and J. D. L. (1968). An investigation of the structural requirements for dopamine-like renal vasodilation: Phenylethyl amines and apomorphine. J. Pharmacol. Exp. Ther. 163, 188197. I. and Toda, N. (1975). Dopamine induced relaxation of isolated canine renal, mesenteric, and femoral arteries contracted with prostaglandin F 2 . Circ. Res. Supple. I, 1-97 - 1-102. D. (1978). A comparison of the vascular dopamine receptor with other dopamine receptors. Ann. Rev. Pharmacol. Toxicol.
When the experiment was carried out in the presence of 100 nM S-sulpiride, no such inhibition was observed, indicating that the in hibition caused by (-)NCA is mediated via a dopamine receptor. Further experi ments have shown that the action of (-)NCA on the dopamine autoreceptor is re versible. Thus (-) NCA appears to be a reversible dopamine autoreceptor agon ist, while it is also an irreversible postsynaptic dopamine receptor antagonist in vitro and in vivo. 31 Central Pre- and Post-synaptic Dopamine Receptors _, o iz o 100 u o 50 < < 0 L H/- 10 30 100 1000 [PERGOLIDE] nM Fig.
Advances in Dopamine Research. Proceedings of a Satellite Symposium to the 8th International Congress of Pharmacology, Okayama, Japan, July 1981 by M. Kohsaka, T. Shohmori and Y. Tsukada (Eds.)